From Potency to Performance: How Pharmacokinetic Insights Shape the Hit-to-Lead Transition
It is a very important issue in the competitive world of drug discovery to identify compounds not only that bind with high affinity to a target, but also that perform in a predictable manner in the body. Conventionally, the hit-to-lead (H2L) step was largely concerned with the enhancement of potency and selectivity, i.e., the level […]









